April 15, 2021 Researchers from Faculty of Dentistry, Chulalongkorn University and their collaborator from Graduate School of Dentistry, Tohoku University published the narrative review article in Archives of Oral Biology describing the regulation of stem cell behaviors by mechanical force.
The review briefly explained the definition of mechanical force and mechanical model for cell culture. Subsequently, the mechanosenser was discussed to determine how cells sense the external mechanical stimuli. Mechanical force regulation on stem cells was described focusing on the control of stemness and differentiation toward mesodermal lineages. Lastly, the role of mechanical force on oral stem cells was reviewed.
This review elucidates the potential utilization of mechanical force in controlling stem cell response in vitro. This could be used to precisely control appropriate stem cell behavior toward specific applications.
Reference
Manokawinchoke J, Pavasant P, Limjeerajarus CN, Limjeerajarus N, Osathanon T, Egusa H. Mechanical loading and the control of stem cell behavior. Arch Oral Biol. 2021 Feb 24;125:105092. doi: 10.1016/j.archoralbio.2021.105092.
https://www.sciencedirect.com/science/article/abs/pii/S0003996921000558?via%3Dihub